Search results for "ER STRESS"
showing 10 items of 109 documents
Bortezomib potentiates the antitumor effect of tributyltin(IV) ferulate in colon cancer cells exacerbating ER stress and promoting apoptosis
2022
Organotin(IV) complexes represent promising drugs in medicinal chemistry for their potential use in cancer therapy. We recently reported synthesis and characterization of a new organotin(IV) complex of ferulic acid (FA), tributyltin(IV) ferulate (TBT-F), showing its antitumor action in colon cancer cells. Here we provide evidence that the efficacy of this compound is strongly potentiated by the proteasome inhibitor bortezomib (BTZ). While low concentrations of tributyltin(IV) ferulate alone promoted autophagy without reducing cell viability, combination of the two compounds markedly affected colon cancer cell viability, cell morphology and exasperated endoplasmic reticulum (ER) stress, as r…
Understanding of pea capacity to recover in terms of growth and nitrogen acquisition after water stress : molecular and ecophysiologic studies
2020
Pea (Pisum sativum L.) has the unique ability to fix atmospheric dinitrogen (N2) via a symbiosis with soil bacteria in root nodules. Although this specificity makes this crop particularly interesting in the context of agroecological transition, symbiotic nitrogen fixation is particularly sensitive to abiotic stresses such as water deficit, which contributes to the yield instability of this protein crop and reduces its interest for farmers. Yield stability depends both on plant's ability to tolerate stress and on its ability to recover after stress. However, the mechanisms involved during the recovery period have been for now poorly explored. It is, therefore, essential to identify traits of…
Assessment of MODIS imagery to track light-use efficiency in a water-limited Mediterranean pine forest
2012
Abstract Daily values of gross primary production ( GPP ) derived from an eddy-covariance flux tower have been used to analyze the information content of the MODIS Photochemical Reflectance Index ( PRI ) on the light-use efficiency ( e ). The study has been conducted in a Mediterranean Pinus pinaster forest showing summer water stress. Advanced processing techniques have been used to analyze the effect of various external factors on e and PRI temporal variations. The intra-annual correlation between these two variables has been found to be mostly attributable to concurrent variations in sun and view zenith angles. The PRI has been normalized from these angular effects ( NPRI ), and its abil…
ECOHYDROLOGICAL MODELLING IN MEDITERRANEAN AREAS AND WETLANDS
2010
La seguente dissertazione verte sul campo di ricerca noto come Ecoidrologia. Sebbene tale scienza, che studia le mutue interazioni fra ciclo idrologico e gli ecosistemi naturali, sia stata recentemente oggetto di svariati studi, alcuni dei suoi numerosi aspetti rimangono tuttavia ancora alquanto inesplorati. L’obiettivo principale della presente tesi è quello di rivisitare la letteratura scientifica esistente sull’argomento, cercando di adattare concetti e modelli sviluppati per certi ecosistemi anche alle peculiarità di altri ambienti meno studiati, come quelli aridi e semiaridi tipici della zona Mediterranea o le cosiddette “wetlands”, zone umide e paludose. In particolare, viene approfon…
Metabolic profiling of ripe olive fruit in response to moderate water stress
2013
a b s t r a c t The concentrations of different metabolites in olive (Olea europaea (L.)) fruit at harvest can be affected by water availability, with significant consequences on the composition and the quality of the resulting oil. The aim of the present study was to profile the metabolic composition of ripe olives (cv. Cipressino) grown under water-stress and irrigated conditions applied during the last part of the fruit developmental cycle (from pit hardening to commercial harvest). The imposed conditions resulted in a moderate water stress (−3.5 MPa) at the end of the experimental period. Samples (pulp + skin) of fruit collected at the stage of complete epicarp pigmentation were analyze…
Left Ventricle Biomechanics of Low-Flow, Low-Gradient Aortic Stenosis: A Patient-Specific Computational Model
2022
This study aimed to create an imaging-derived patient-specific computational model of low-flow, low-gradient (LFLG) aortic stenosis (AS) to obtain biomechanics data about the left ventricle. LFLG AS is now a commonly recognized sub-type of aortic stenosis. There remains much controversy over its management, and investigation into ventricular biomechanics may elucidate pathophysiology and better identify patients for valve replacement. ECG-gated cardiac computed tomography images from a patient with LFLG AS were obtained to provide patient-specific geometry for the computational model. Surfaces of the left atrium, left ventricle (LV), and outflow track were segmented. A previously validated …
Early assessment of crop yield from remotely sensed water stress and solar radiation data
2018
Soil moisture (SM) available for evapotranspiration is crucial for food security, given the significant interannual yield variability of rainfed crops in large agricultural regions. Also, incoming solar radiation (Rs) influences the photosynthetic rate of vegetated surfaces and can affect productivity. The aim of this work is to evaluate the ability of crop water stress and Rs remotely sensed data to forecast yield at regional scale. Temperature Vegetation Dryness Index (TVDI) was computed as an indicator of crop water stress and soil moisture availability. TVDI during critical growth stage of crops was calculated from MODIS products: MODIS/AQUA 8-day composite LST at 1 km and 16-day compos…
Agro-hydrological models and field measurements to assess the water status of a citrus orchard irrigated with micro-sprinkler and subsurface drip sys…
2021
Compared to the micro-sprinkler irrigation, traditionally used in citrus orchards, subsurface drip systems (SDS) allow increasing the water use efficiency (WUE); when coupled with water-saving strategies, like regulated deficit irrigation (RDI), further increase of WUE are possible. Combining measurements of soil water content (SWC) and weather data with measurements of midday stem water potential (MSWP) makes it possible to identify irrigation scheduling parameters for the RDI. However, measurements of MSWP are destructive and time-consuming, and also require skilled operators. For all these reasons, the use of the agro-hydrological models, such as the FAO-56 model, can be considered a sur…
Simulación de flujos de carbono terrestres mediante teledetección y modelización de ecosistemas
2019
[EN] The main goal of this thesis is the establishment of a framework to analyze the forest ecosystems in peninsular Spain in terms of their role in the carbon cycle. In particular, the carbon fluxes that they exchange with atmosphere are modeled to evaluate their potential as carbon sinks and biomass reservoirs. The assessment of gross and net carbon fluxes is performed at 1-km spatial scale and on a daily basis using two different ecosystem models, Monteith and BIOME-BGC, respectively. These models are driven by a combination of satellite and ground data, part of the latter being also employed as a complementary data source and in the validation process. [ES] El objetivo principal de esta…
The Indian-French Trishna Mission: Earth Observation in the Thermal Infrared with High Spatio-Temporal Resolution
2018
International audience; The monitoring of the water cycle at the Earth surface which tightly interacts with the climate change processes as well as a number of practical applications (agriculture, soil and water quality assessment, irrigation and water resource management, etc...) requires surface temperature measurements at local scale. Such is the goal of the Indian-French high spatio-temporal TRISHNA mission (Thermal infraRed Imaging Satellite for High-resolution Natural resource Assessment). The scientific objectives of the mission and research work conducted to consolidate the mission specifications are presented. Progress in modelling of surface fluxes is then discussed. The main spec…